Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms-Report of three cases

Anna Kelemen, Péter Barsi, Zsuzsanna Gyorsok, Judit Sarac, Anna Szucs, Péter Halász

Research output: Article

45 Citations (Scopus)

Abstract

We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau-Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in slow wave sleep (ESES). The third patient has a dominantly unilateral thalamic tumor and epilepsy that mimics juvenile myoclonic epilepsy. All the patients have a lesion located in the inferior-medial-posterior part of the thalamus. The role of some thalamic and subthalamic nuclei in the generalized spike-wave electrical pattern patophysiology is discussed, with emphasis on the possible role of the inhibitory system from the zona incerta.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalSeizure
Volume15
Issue number6
DOIs
Publication statusPublished - szept. 1 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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