Testing of the structure of macromolecular polymer films containing solid active pharmaceutical ingredient (API) particles

É Bölcskei, K. Süvegh, T. Marek, G. Regdon, K. Pintye-Hódi

Research output: Article

5 Citations (Scopus)

Abstract

The aim of the present study was to investigate the structure of free films of Eudragit® L 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17°C, 65% relative humidity (RH)) in consequence of the uptake of water from the air.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalRadiation Physics and Chemistry
Volume80
Issue number7
DOIs
Publication statusPublished - júl. 1 2011

ASJC Scopus subject areas

  • Radiation

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