T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange

Karin R. Sipido, Károly Acsai, Gudrun Antoons, Virginie Bito, Niall MacQuaide

Research output: Conference contribution

9 Citations (Scopus)

Abstract

The Na+/Ca2+ exchanger (NCX) is a key regulator of intracellular Ca2+ in cardiac myocytes, predominantly contributing to Ca2+ removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca2+ channels face ryanodine receptors (RyRs), the Ca2+ release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca2+ release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca2+ events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca2+ gradients at the level of the dyadic space.

Original languageEnglish
Title of host publicationSodium Calcium Exchange
Subtitle of host publicationA Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange
EditorsLucio Annunziato
Pages375-383
Number of pages9
DOIs
Publication statusPublished - febr. 15 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume961
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sipido, K. R., Acsai, K., Antoons, G., Bito, V., & MacQuaide, N. (2013). T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange. In L. Annunziato (Ed.), Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange (pp. 375-383). (Advances in Experimental Medicine and Biology; Vol. 961). https://doi.org/10.1007/978-1-4614-4756-6-32