11C labelled choline was synthesized by two methods. The conventional method resulted in the product at 130 °C in 20 minutes while the solid phase extraction technique was carried out at room temperature in much less time. The quality control was carried out using HPLC method. As the first biological experiments the cellular uptake of 11C-choline was investigated in human cell lines. The effect of multidrug resistance on the uptake was also studied.
|Translated title of the contribution||Synthesis of11C-choline using the solid phase extraction technique|
|Number of pages||5|
|Journal||Magyar Kemiai Folyoirat, Kemiai Kozlemenyek|
|Publication status||Published - júl. 1 2002|
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