Synthesis of sulfonic acid analogues of the non-reducing end trisaccharide of the antithrombin binding domain of heparin

László Lázár, Mihály Herczeg, Anikó Fekete, Anikó Borbás, András Lipták, Sándor Antus

Research output: Article

11 Citations (Scopus)


Three sulfonic acid trisaccharides related to the antithrombin-binding DEFGH domain of heparin were synthesised. Trisaccharides carrying the sulfonatomethyl moiety at position 2 or 6 were prepared in high yields by [DE+F] couplings using the same disaccharide uronate donor and the appropriate sulfonic acid acceptor, respectively. The trisaccharide with a 3-deoxy-3-sulfonatomethyl function could be obtained with high efficacy by a [D+EF] coupling where the carboxylic function of the EF uronate acceptor was created at a disaccharide level.

Original languageEnglish
Pages (from-to)6711-6714
Number of pages4
JournalTetrahedron Letters
Issue number51
Publication statusPublished - dec. 22 2010


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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