Synthesis of secondary phosphine oxides by substitution at phosphorus by Grignard reagents

Anna Tripolszky, G. Keglevich

Research output: Review article

2 Citations (Scopus)


Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two different substituents is of special importance. This minireview gives useful hints for the synthesis of a variety of SPOs that are useful intermediates.

Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalLetters in Organic Chemistry
Issue number5
Publication statusPublished - máj. 1 2018


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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