Synthesis of imidazo[1′,5′:1,2]pyrido [3,4-b]indole derivatives

Magdolna Solymár, Márta Palkó, Tamás Martinek, Ferenc Fülöp

Research output: Article

2 Citations (Scopus)


The reactions of 1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid and its ethyl ester with alkyl and aryl isothiocyanates under mild conditions resulted in the corresponding thiohydantoin-fused tetrahydro-β-carbolines. Treatment of the ethyl ester with isocyanates furnished ethyl 2-alkyl- or arylcarbamoyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylates which were transformed to hydantoinfused tetrahydro-β-carbolines. The structures of the thiohydantoin compounds, involving two conformers and the presence of keto-enol tautomerism, were determined by NMR spectroscopy.

Original languageEnglish
Pages (from-to)1423-1430
Number of pages8
JournalMonatshefte fur Chemie
Issue number11
Publication statusPublished - nov. 18 2002


ASJC Scopus subject areas

  • Chemistry(all)

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