Synthesis of E- and Z-o-methoxy-substituted 2,3-diphenyl propenoic acids and its methyl esters

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A series of stereoisomeric o-methoxy-substituted 2,3-diphenyl propenoic acids and their methyl esters have been synthesized. The E isomers were prepared by a modified Perkin condensation (substituted benzaldehyde, phenylacetic acid, Et3N/acetic anhydride). The difficult to access Z isomers were obtained conveniently in good yields when the appropriate coumarin derivatives were allowed to react with KOH and CH3I in DMSO.

Original languageEnglish
Pages (from-to)1543-1553
Number of pages11
JournalSynthetic Communications
Issue number9
Publication statusPublished - jan. 1 2000


ASJC Scopus subject areas

  • Organic Chemistry

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