Synthesis of disaccharide fragments of the AT-III binding domain of heparin and their sulfonatomethyl analogues

Mihály Herczeg, László Lázár, Attila Mándi, Anikó Borbás, István Komáromi, András Lipták, Sándor Antus

Research output: Article

17 Citations (Scopus)

Abstract

D-Glucuronate and L-iduronate-containing disaccharides related to the antithrombin-binding domain of heparin were prepared. The carboxylic function of the uronic acid unit was formed on a disaccharide level in the case of the glucuronate, while on a monosaccharide level in the case of the iduronate derivatives. Synthesis of their sulfonic acid analogues was carried out analoguosly applying sulfonatomethylcontaining acceptors in the form of either salts or methyl esters. Significant difference could be observed in the methyl ether formation reactions of the sulfonatomethyl-containing uronate disaccharides and the non-sulfonic acid uronates.

Original languageEnglish
Pages (from-to)1827-1836
Number of pages10
JournalCarbohydrate Research
Volume346
Issue number13
DOIs
Publication statusPublished - szept. 2011

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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