Synthesis of cyclic aminomethylphosphonates and aminomethyl-arylphosphinic acids by an efficient microwave-mediated phospha-mannich approach

György Keglevich, Anna Szekrényi, Melinda Sipos, Krisztina Ludányi, István Greiner

Research output: Article

34 Citations (Scopus)


Microwave-assisted condensation of 1,3,-2-dioxaphosphinane 2-oxide (1), paraformaldehyde and secondary amines including 5- and 6-membered N-heterocycles at 55°C gave cyclic aminomethylphosphonates (2), whereas an analogous reaction involving dibenzo[c.e][1,2]oxaphosphinane 2-oxide (3) resulted in the corresponding aminomethyl-2-(2′-hydroxybiphenyl)phosphinic acids (4) as a consequence of a hydrolytic ring opening following the condensation.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalHeteroatom Chemistry
Issue number2
Publication statusPublished - márc. 19 2008


ASJC Scopus subject areas

  • Chemistry(all)

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