The C-1 epimers of the 3-methyl-6,7-dimethoxy analogues of the D 4 antagonist sonepiprazole 1b and 5-HT1D agonist PNU-109291 1a containing both the isochroman and p-methoxyphenylpiperazine chromophores were prepared in order to study the applicability of circular dichroism for the assignment of the configuration of 1,3-disubstituted isochromans and test their dopamine D4 antagonist activity.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry