Synthesis and circular dichroism of optically active 1,3-disubstituted isochromans of dopamine D4 antagonist activity

Gábor Kerti, Tibor Kurtán, Katalin E. Kövér, Sándor Sólyom, István Greiner, Sándor Antus

Research output: Article

6 Citations (Scopus)

Abstract

The C-1 epimers of the 3-methyl-6,7-dimethoxy analogues of the D 4 antagonist sonepiprazole 1b and 5-HT1D agonist PNU-109291 1a containing both the isochroman and p-methoxyphenylpiperazine chromophores were prepared in order to study the applicability of circular dichroism for the assignment of the configuration of 1,3-disubstituted isochromans and test their dopamine D4 antagonist activity.

Original languageEnglish
Pages (from-to)2356-2360
Number of pages5
JournalTetrahedron Asymmetry
Volume21
Issue number19
DOIs
Publication statusPublished - okt. 7 2010

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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