Syntheses of (E)- and (Z)-3-styrylchromones

Vera L.M. Silva, Artur M.S. Silva, Diana C.G.A. Pinto, José A.S. Cavaleiro, Attila Vasas, Tamás Patonay

Research output: Article

10 Citations (Scopus)


Several (E)- and (Z)-3-styrylchromones were prepared by two different methodologies, the Wittig reaction of chromone-3-carboxaldehyde with benzylic ylides and the Knoevenagel condensation of chromone-3-carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under microwave irradiation. The Knoevenagel reaction followed by a decarboxylation offered an efficient and diastereoselective method for preparing (E)-3-styrylchromones in a shorter reaction time. It was also demonstrated that phenylacetic acid can also be substituted with success by phenylmalonic acid. The stereochemistry of all products was assigned by NMR experiments.

Original languageEnglish
Pages (from-to)1307-1315
Number of pages9
JournalMonatshefte fur Chemie
Issue number11
Publication statusPublished - nov. 1 2008

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Syntheses of (E)- and (Z)-3-styrylchromones'. Together they form a unique fingerprint.

  • Cite this

    Silva, V. L. M., Silva, A. M. S., Pinto, D. C. G. A., Cavaleiro, J. A. S., Vasas, A., & Patonay, T. (2008). Syntheses of (E)- and (Z)-3-styrylchromones. Monatshefte fur Chemie, 139(11), 1307-1315.