Sympathetic control of substance P releasing enteric neurones in the guinea pig ileum

L. Barthó, P. Holzer, F. Lembeck

Research output: Article

29 Citations (Scopus)

Abstract

The contractile response of the isolated guinea-pig ileum to cholecystokinin octapeptide (CCK-8) that remained in the presence of atropine was greatly inhibited by the substance P antagonist d-Pro2, d-Trp7.9-substance P. This indicates that the atropine-resistant contraction to CCK-8 is mediated by the release of substance P from enteric neurones. Activation of α-adrenergic receptors by noradrenaline, clonidine or mesenteric sympathetic nerve stimulation inhibited the atropine-resistant contraction to CCK-8 but did not affect the contractile effect of substance P. It is concluded that α-adrenergic receptors exert an inhibitory influence on the release of substance P from enteric neurones.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalNeuroscience Letters
Volume38
Issue number3
DOIs
Publication statusPublished - aug. 8 1983

ASJC Scopus subject areas

  • Neuroscience(all)

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