Switching on RNA silencing suppressor activity by restoring argonaute binding to a viral protein

Edit Z. Szabó, Máté Manczinger, Anikó Göblös, Lajos Kemény, Lóránt Lakatos

Research output: Article

19 Citations (Scopus)

Abstract

We found that Sweet potato feathery mottle virus (SPFMV) P1, a close homologue of Sweet potato mild mottle virus P1, did not have any silencing suppressor activity. Remodeling the Argonaute (AGO) binding domain of SPFMV P1 by the introduction of two additional WG/GW motifs converted it to a silencing suppressor with AGO binding capacity. To our knowledge, this is the first instance of the transformation of a viral protein of unknown function to a functional silencing suppressor.

Original languageEnglish
Pages (from-to)8324-8327
Number of pages4
JournalJournal of Virology
Volume86
Issue number15
DOIs
Publication statusPublished - aug. 2 2012

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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