Surface treatment of indomethacin agglomerates with Eudragit

János Bajdik, K. Pintye-Hódi, Odon Planinšek, Zsófia Tüske, Ljiljana Tasic, Géza Regdon, Stane Srčič, I. Erös

Research output: Article

14 Citations (Scopus)

Abstract

Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalDrug Development and Industrial Pharmacy
Volume30
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

Indomethacin
Surface treatment
Coatings
Capsules
Pharmaceutical Preparations
Gastric Juice
Dosage Forms
Crystals
Gastrointestinal Tract
Dissolution
Mucous Membrane
Anti-Inflammatory Agents
Free energy
Wetting
methylmethacrylate-methacrylic acid copolymer
Adhesion
Agglomeration

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Surface treatment of indomethacin agglomerates with Eudragit. / Bajdik, János; Pintye-Hódi, K.; Planinšek, Odon; Tüske, Zsófia; Tasic, Ljiljana; Regdon, Géza; Srčič, Stane; Erös, I.

In: Drug Development and Industrial Pharmacy, Vol. 30, No. 4, 2004, p. 381-388.

Research output: Article

Bajdik, J, Pintye-Hódi, K, Planinšek, O, Tüske, Z, Tasic, L, Regdon, G, Srčič, S & Erös, I 2004, 'Surface treatment of indomethacin agglomerates with Eudragit', Drug Development and Industrial Pharmacy, vol. 30, no. 4, pp. 381-388. https://doi.org/10.1081/DDC-120030932
Bajdik, János ; Pintye-Hódi, K. ; Planinšek, Odon ; Tüske, Zsófia ; Tasic, Ljiljana ; Regdon, Géza ; Srčič, Stane ; Erös, I. / Surface treatment of indomethacin agglomerates with Eudragit. In: Drug Development and Industrial Pharmacy. 2004 ; Vol. 30, No. 4. pp. 381-388.
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AU - Tüske, Zsófia

AU - Tasic, Ljiljana

AU - Regdon, Géza

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