Surface heterogeneity of tumor cells and changes upon ionizing radiation

Z. Somosy, O. Csuka, T. Kubasova, J. Kovacs, G. J. Koteles

Research output: Review article

4 Citations (Scopus)


Heterogeneous distribution of surface domains is a characteristic feature of the tumor cell surface and the distribution differs from that of normal cells. During the malignant transformation the heterogeneity may change or disappear. Cell lines with various metastasizing capacities show different distributions of membrane domains or other differences in membrane or surface organization. We have demonstrated that the amount and distribution of negatively charged sites of B 16 melanoma membranes changed upon ionizing radiation (X-ray, 60Co-gamma). In the case of the P 388 lymphoma, however, only the amount of negatively charged sites change after irradiation, the distribution remains unaltered. Both features proved to be radioresistant in human lymphoid leukemic cells.

Original languageEnglish
Pages (from-to)895-906
Number of pages12
JournalScanning Microscopy
Issue number3
Publication statusPublished - dec. 1 1989


ASJC Scopus subject areas

  • Instrumentation

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