18F-FDG-PET/CT-vel szerzett tapasztalataink az aktív nagyérvasculitisek diagnosztikájában és differenciáldiagnózisában: Prospektív vizsgálat

Bakos Annamária, Besenyi Zsuzsanna, Sipka Gábor, Urbán Szabolcs, Hemelein Rita, Kovács László, Pávics László

Research output: Article

Abstract

Introduction: Large-vessel vasculitis has non-specific clinical symptoms, which can delay the diagnosis. Early recognition and treatment of the disease can help to avoid late complications. 18F-FDG-PET can detect the inflammation of the vessel wall in the early stage of the disease with high sensitivity. CT is used to localize vasculitis. Aim: To examine the performance of 18F-FDG-PET/CT in patients with suspected large-vessel vasculitis, during relapse and remission, focusing on disease activity and extent. Method: 43 patients were evaluated. They were classified according to the clinical questions: steroid-naive suspected vasculitis, suspected vasculitis on steroid treatment, patients with relapse and in remission. We examined 10 cancer patients in control. We carried out visual and quantitative analysis of the 18F-FDG uptake of vessel walls. During quantitative evaluation, we determined standardised uptake values (SUVmax) of vessel wall segments compared to liver. Results: We found active disease in 5 patients examined for primary diagnosis, moreover, in 5 patients with relapse. The disease involved 3 or more vessel segments in fifty percent of the active cases. In the visually active group, the SUVmax was significantly lower in patients on steroid treatment than in steroid-naive cases (1.17 ± 0.11 vs. 1.43 ± 0.29; p = 0.005). We confirmed remission in 2 cases after therapy. In the inactive group, we found other types of inflammatory disorders in 8 cases. Conclusion: 18F-FDG-PET/CT is an effective diagnostic tool for large-vessel vasculitis, and can be used to determine the activity and extent of the disease. Steroid treatment influences the 18F-FDG-uptake of vessel wall.

Translated title of the contribution18F-FDG-PET/CT in the evaluation and differential diagnosis of active large-vessel vasculitis: A prospective study
Original languageHungarian
Pages (from-to)829-838
Number of pages10
JournalOrvosi hetilap
Volume161
Issue number20
DOIs
Publication statusPublished - máj. 2020

Keywords

  • F-fluorodeoxyglucose positron emission tomography
  • 18F-FDG-PET/CT
  • Large-vessel vasculitis

ASJC Scopus subject areas

  • Medicine(all)

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