The roles of transmembrane proteins in living cells are diverse. They are involved in the transport of various solutes and information through membranes, in energy production, in metabolism and more. Despite their biological importance, the number of their structures in Protein Data Base is rather low compared to the number of globular proteins, due to the technical difficulties originating from the fact that these proteins live in a dual environment. Therefore, modeling structures of transmembrane proteins is crucial, as in many cases it is almost the only available technique to get structural information about these proteins. Here we summarize the most important structural aspects of transmembrane proteins and the state-of-the-art methods capable generating their structures in various dimensions: from predicting topography and topology through the 3D structure, oligomer formation to the orientation in the membrane.
|Title of host publication||Protein Modelling|
|Publisher||Springer International Publishing|
|Number of pages||23|
|ISBN (Print)||3319099752, 9783319099750|
|Publication status||Published - júl. 1 2014|
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