Stromal myofibroblasts in breast cancer

Relations between their occurrence, tumor grade and expression of some tumour markers

Paweł Surowiak, Sławomir Suchocki, B. Györffy, Tserenchunt Gansukh, Andrzej Wojnar, Adam Maciejczyk, Marek Pudełko, Maciej Zabel

Research output: Article

32 Citations (Scopus)

Abstract

It is suggested that tumour stromal myofibroblasts exert an unfavourable effect on the biology of breast cancer. We are aware of only a single study which examined relationships between manifestation of myofibroblasts in the stroma of breast cancer and clinicopathological data of the patients. The present study was aimed at estimation of the effect exerted by myofibroblasts present in the tumour stroma on principal pathological parameters and on expression of Ki67, P53 and HER-2 proteins in the group of the most frequent breast cancers, the ductal cancers. In paraffin sections of 60 ductal breast cancers (20 cases in G1, 20 in G2 and 20 in G3), immunohistochemical reactions were performed to detect expression of smooth muscle actin (SMA) in order to visualize myofibroblasts, Ki67, P53 and HER-2. The studies demonstrated that the most numerous myofibroblasts were present in G3 cases and they were the least frequent in G1 cases (P=0.02). Positive correlations were observed between the presence of myofibroblasts in tumour stroma and expression of Ki67 and HER-2 in breast cancer cells in the entire group (P

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalFolia Histochemica et Cytobiologica
Volume44
Issue number2
Publication statusPublished - 2006

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Myofibroblasts
Tumor Biomarkers
Breast Neoplasms
Neoplasms
Paraffin
Smooth Muscle
Actins
Proteins

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Stromal myofibroblasts in breast cancer : Relations between their occurrence, tumor grade and expression of some tumour markers. / Surowiak, Paweł; Suchocki, Sławomir; Györffy, B.; Gansukh, Tserenchunt; Wojnar, Andrzej; Maciejczyk, Adam; Pudełko, Marek; Zabel, Maciej.

In: Folia Histochemica et Cytobiologica, Vol. 44, No. 2, 2006, p. 111-116.

Research output: Article

Surowiak, P, Suchocki, S, Györffy, B, Gansukh, T, Wojnar, A, Maciejczyk, A, Pudełko, M & Zabel, M 2006, 'Stromal myofibroblasts in breast cancer: Relations between their occurrence, tumor grade and expression of some tumour markers', Folia Histochemica et Cytobiologica, vol. 44, no. 2, pp. 111-116.
Surowiak, Paweł ; Suchocki, Sławomir ; Györffy, B. ; Gansukh, Tserenchunt ; Wojnar, Andrzej ; Maciejczyk, Adam ; Pudełko, Marek ; Zabel, Maciej. / Stromal myofibroblasts in breast cancer : Relations between their occurrence, tumor grade and expression of some tumour markers. In: Folia Histochemica et Cytobiologica. 2006 ; Vol. 44, No. 2. pp. 111-116.
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