Lymphocyte glucocorticoid receptors (GCR) in 18 children with nephrotic syndrome, and 4 children of similar age, who did not have renal disease, were studied. Flow cytometry was used to measure the GCR positivity by monoclonal antibody. The number of GCR+, CD3, CD4 and CD8 lymphocytes were analyzed. The proportion of GCR+ cells in each group was related to steroid responsiveness. The ratio of the proportion of CD4+ cells, compared with CD8+ cells, was low in children who did not respond to steroids, and high in steroid responsive children.
|Number of pages||4|
|Publication status||Published - jan. 1 2002|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health