Steroid responsiveness in nephrotic syndrome: Related to the elevated glucocorticoid binding in CD4+ T-cell subset

M. Visy, E. Ujhelyi, T. Berki, G. Lustyik, L. Grama, A. Falus

Research output: Article

Abstract

Lymphocyte glucocorticoid receptors (GCR) in 18 children with nephrotic syndrome, and 4 children of similar age, who did not have renal disease, were studied. Flow cytometry was used to measure the GCR positivity by monoclonal antibody. The number of GCR+, CD3, CD4 and CD8 lymphocytes were analyzed. The proportion of GCR+ cells in each group was related to steroid responsiveness. The ratio of the proportion of CD4+ cells, compared with CD8+ cells, was low in children who did not respond to steroids, and high in steroid responsive children.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalInternational Pediatrics
Volume17
Issue number1
Publication statusPublished - jan. 1 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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