Stereoselective synthesis of hydroxylated β-aminocyclohexanecarboxylic acids

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35 Citations (Scopus)

Abstract

A simple synthetic approach has been developed for the regio- and diastereoselective synthesis of hydroxylated 2-aminocyclohexanecarboxylic acid stereoisomers from 1,4-cyclohexadiene by the reductive opening of appropriate epoxide intermediates derived from the corresponding bicyclic β-lactams. This method has been extended to the synthesis of these hydroxylated β-amino acids in enantiomerically pure form.

Original languageEnglish
Pages (from-to)5036-5043
Number of pages8
JournalTetrahedron
Volume64
Issue number22
DOIs
Publication statusPublished - máj. 26 2008

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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