New steroidal phosphine oxides were obtained by base-catalysed addition of HPPh2 to the C=C double bond of α,β-unsaturated steroidal esters. The presence of Pd(OAc)2 has been shown to accelerate the reaction rate. 16 α-Phosphinyl-17β-metoxycarbonyl-androstane derivatives were formed stereoselectively and isolated in moderate to high yields. The exact structure of the products were determined by various spectroscopic methods including two-dimensional NMR techniques.
ASJC Scopus subject areas
- Organic Chemistry