Stationary ultrafiltration: A radio-tracer technique for studying stereoselective binding of racemic ligands

M. Simonyi, I. Fitos, Zs Tegyey, L. Ötvös

Research output: Article

7 Citations (Scopus)

Abstract

The continuous exchange of the radioactive free ligand by its non-labelled isotopomer of identical concentration does not affect the position of the overall-equilibrium. The replacement of the enantiomer of higher binding affinity lags behind the replacement of the other one that leads to stereoselective labelling of racemates. Radioactivity, as a function of filtrate volume can be fitted to theoretical expressions. The method allows to study stereoselectivity of binding equilibria set by racemic ligands.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalTopics in Catalysis
Volume97
Issue number1
DOIs
Publication statusPublished - jan. 1 1980

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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