Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Gyöngyi Szigeti, Ebrahim Sedaghati, Ali Zarei Mahmoudabadi, Ali Naseri, Sándor Kocsubé, Csaba Vágvölgyi, János Varga

Research output: Article

25 Citations (Scopus)

Abstract

Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalMycoses
Volume55
Issue number4
DOIs
Publication statusPublished - júl. 1 2012

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ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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