Non-steroidal anti-inflammatory drugs have an important impact in the actual medicinal therapy, having indications in covering the range from rheumatic inflammations to cardio-vascular, genito-urinary and stomatological diseases. Flufenamic acid is a nonsteroidal anti-inflammatory drug, from the class of fenamates. It exhibits poor aqueous solubility, accordingly the aim of this study was to enhance flufenamic acid water solubility, through its amorphization using auxiliary substances with macromolecules. Since the preliminary analyses with thermomicroscopy and differential scanning calorimetry (DSC) showed that the flufenamic acid dissolves in the molten polyethylene glycol (PEG), we made solid dispersions of flufenamic acid with PEG 4000 and PEG 6000 through the melting method in 1:5 and 1:10 mass ratio. The solid dispersions were analyzed with DSC, X-Ray Diffraction (XRD) and we made dissolution tests in artificial gastric juice and artificial intestinal juice. Through DSC measurements and thermomicroscopic analysis were verified the amorphization, the dissolution of the flufenamic acid in PEGs. The analysis of the solid dispersions by XRD demonstrates the amorphization of flufenamic acid. The dissolution test shows a 4.4 times better solubility in the artificial gastric juice with the PEG 4000 mixture in 1:10 mass ratio.
|Number of pages||10|
|Publication status||Published - febr. 24 2011|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)