Smoking in inflammatory bowel diseases: Good, bad or ugly?

Research output: Editorial

128 Citations (Scopus)

Abstract

Smoking is an important environmental factor in inflammatory bowel disease (IBD), having different effects in ulcerative colitis (UC) and Crohn's disease (CD). A recent meta-analysis partially confirmed previous findings that smoking was found to be protective against ulcerative colitis and, after onset of the disease, might improve its course, decreasing the need for colectomy. However, smoking increases the risk of developing Crohn's disease and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Smoking cessation aggravates ulcerative colitis and improves Crohn's disease. Data are however, largely conflictive as well as the potential mechanisms involved in this dual relationship are still unknown. In this review article, the authors review the role of smoking in inflammatory bowel diseases.

Original languageEnglish
Pages (from-to)6134-6139
Number of pages6
JournalWorld journal of gastroenterology
Volume13
Issue number46
DOIs
Publication statusPublished - dec. 14 2007

ASJC Scopus subject areas

  • Gastroenterology

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