Simulation of deposition and clearance of inhaled particles in central human airways

I. Balásházy, Á Farkas, I. Szöke, W. Hofmann, R. Sturm

Research output: Article

17 Citations (Scopus)

Abstract

In this study local distributions of deposited inhaled particles such as radon progenies in realistic human airway bifurcation models of bronchial generations one to six are computed for different geometries, inlet flow profiles, flow rates and particle sizes with computational fluid particle dynamics methods. The movement of the mucus layer in the large central human airways is also simulated by computational fluid dynamic techniques. There is experimental evidence that bronchogenic carcinomas mainly originate at the central zone of the large airway bifurcations, where primary hot-spots of deposition have been found. However, current lung deposition models do not take into consideration the inhomogeneity of deposition within the airways. The inhomogeneous movement of the mucus layer may strongly influence the effect of primary deposition. On the basis of our results, both the deposition and the clearance patterns are highly non-uniform, especially in the vicinity of the carinal ridge of the bifurcations.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalRadiation Protection Dosimetry
Volume105
Issue number1-4
Publication statusPublished - 2003

Fingerprint

Bridge clearances
clearances
Hydrodynamics
Mucus
Radon
mucus
Bronchogenic Carcinoma
Particle Size
simulation
Lung
inlet flow
progeny
Inlet flow
computational fluid dynamics
radon
lungs
ridges
Computational fluid dynamics
inhomogeneity
flow velocity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Simulation of deposition and clearance of inhaled particles in central human airways. / Balásházy, I.; Farkas, Á; Szöke, I.; Hofmann, W.; Sturm, R.

In: Radiation Protection Dosimetry, Vol. 105, No. 1-4, 2003, p. 129-132.

Research output: Article

Balásházy, I, Farkas, Á, Szöke, I, Hofmann, W & Sturm, R 2003, 'Simulation of deposition and clearance of inhaled particles in central human airways', Radiation Protection Dosimetry, vol. 105, no. 1-4, pp. 129-132.
Balásházy, I. ; Farkas, Á ; Szöke, I. ; Hofmann, W. ; Sturm, R. / Simulation of deposition and clearance of inhaled particles in central human airways. In: Radiation Protection Dosimetry. 2003 ; Vol. 105, No. 1-4. pp. 129-132.
@article{812c363b51fd413d95d0a39f41ea9f9f,
title = "Simulation of deposition and clearance of inhaled particles in central human airways",
abstract = "In this study local distributions of deposited inhaled particles such as radon progenies in realistic human airway bifurcation models of bronchial generations one to six are computed for different geometries, inlet flow profiles, flow rates and particle sizes with computational fluid particle dynamics methods. The movement of the mucus layer in the large central human airways is also simulated by computational fluid dynamic techniques. There is experimental evidence that bronchogenic carcinomas mainly originate at the central zone of the large airway bifurcations, where primary hot-spots of deposition have been found. However, current lung deposition models do not take into consideration the inhomogeneity of deposition within the airways. The inhomogeneous movement of the mucus layer may strongly influence the effect of primary deposition. On the basis of our results, both the deposition and the clearance patterns are highly non-uniform, especially in the vicinity of the carinal ridge of the bifurcations.",
author = "I. Bal{\'a}sh{\'a}zy and {\'A} Farkas and I. Sz{\"o}ke and W. Hofmann and R. Sturm",
year = "2003",
language = "English",
volume = "105",
pages = "129--132",
journal = "Radiation Protection Dosimetry",
issn = "0144-8420",
publisher = "Oxford University Press",
number = "1-4",

}

TY - JOUR

T1 - Simulation of deposition and clearance of inhaled particles in central human airways

AU - Balásházy, I.

AU - Farkas, Á

AU - Szöke, I.

AU - Hofmann, W.

AU - Sturm, R.

PY - 2003

Y1 - 2003

N2 - In this study local distributions of deposited inhaled particles such as radon progenies in realistic human airway bifurcation models of bronchial generations one to six are computed for different geometries, inlet flow profiles, flow rates and particle sizes with computational fluid particle dynamics methods. The movement of the mucus layer in the large central human airways is also simulated by computational fluid dynamic techniques. There is experimental evidence that bronchogenic carcinomas mainly originate at the central zone of the large airway bifurcations, where primary hot-spots of deposition have been found. However, current lung deposition models do not take into consideration the inhomogeneity of deposition within the airways. The inhomogeneous movement of the mucus layer may strongly influence the effect of primary deposition. On the basis of our results, both the deposition and the clearance patterns are highly non-uniform, especially in the vicinity of the carinal ridge of the bifurcations.

AB - In this study local distributions of deposited inhaled particles such as radon progenies in realistic human airway bifurcation models of bronchial generations one to six are computed for different geometries, inlet flow profiles, flow rates and particle sizes with computational fluid particle dynamics methods. The movement of the mucus layer in the large central human airways is also simulated by computational fluid dynamic techniques. There is experimental evidence that bronchogenic carcinomas mainly originate at the central zone of the large airway bifurcations, where primary hot-spots of deposition have been found. However, current lung deposition models do not take into consideration the inhomogeneity of deposition within the airways. The inhomogeneous movement of the mucus layer may strongly influence the effect of primary deposition. On the basis of our results, both the deposition and the clearance patterns are highly non-uniform, especially in the vicinity of the carinal ridge of the bifurcations.

UR - http://www.scopus.com/inward/record.url?scp=0141564800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141564800&partnerID=8YFLogxK

M3 - Article

C2 - 14526942

AN - SCOPUS:0141564800

VL - 105

SP - 129

EP - 132

JO - Radiation Protection Dosimetry

JF - Radiation Protection Dosimetry

SN - 0144-8420

IS - 1-4

ER -