Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome

J. Bene, Magdolna Márton, M. Mohás, Zoltán Bagosi, Zoltán Bujtor, Tamás Oroszlán, B. Gasztonyi, I. Wittmann, B. Melegh

Research output: Article

21 Citations (Scopus)

Abstract

Background/Aims: In type 1 diabetes (T1D), type 2 diabetes (T2D) and metabolic syndrome (MetS), the associated complex metabolomic changes in the involvement of carnitine metabolism in total carnitine ester level has already been documented; here we extended the investigations to the individual acylcarnitines. Methods: The fasting serum acylcarnitine concentrations were determined in 49 T1D, 38 T2D and 38 MetS patients and 40 controls by isotope dilution electrospray ionization tandem mass spectrometry. Results: The acylcarnitine profiles of the 3patient groups shared elements with the controls. Considerably higher levels of almost all short-chain acylcarnitines (p <0.05) and lower levels of some long-chain acylcarnitines were detected in T2D and MetS patients. The amounts of C3 and C4 carnitine were higher and most of the medium-chain and long-chain acylcarnitine levels were lower (p <0.05) in T1D and MetS patients than in the controls. In T1D and T2D, the levels of C3 and C4 acylcarnitines were markedly elevated and some long-chain acylcarnitines were lower than the controls (p <0.05). Moreover, significantly lower concentrations of free-and total carnitine were observed in T1D patients (p <0.05). Conclusions: Profound alterations were detected in acylcarnitine profiles in the 3 patient groups. Similarities in the patterns suggest different degrees of involvement of the same metabolic systems in a systems biology approach.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume62
Issue number1
DOIs
Publication statusPublished - jan. 2013

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Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Carnitine
Serum
acylcarnitine
Metabolomics
Systems Biology
Electrospray Ionization Mass Spectrometry
Tandem Mass Spectrometry
Isotopes
Fasting
Esters

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Similarities in serum acylcarnitine patterns in type 1 and type 2 diabetes mellitus and in metabolic syndrome. / Bene, J.; Márton, Magdolna; Mohás, M.; Bagosi, Zoltán; Bujtor, Zoltán; Oroszlán, Tamás; Gasztonyi, B.; Wittmann, I.; Melegh, B.

In: Annals of Nutrition and Metabolism, Vol. 62, No. 1, 01.2013, p. 80-85.

Research output: Article

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abstract = "Background/Aims: In type 1 diabetes (T1D), type 2 diabetes (T2D) and metabolic syndrome (MetS), the associated complex metabolomic changes in the involvement of carnitine metabolism in total carnitine ester level has already been documented; here we extended the investigations to the individual acylcarnitines. Methods: The fasting serum acylcarnitine concentrations were determined in 49 T1D, 38 T2D and 38 MetS patients and 40 controls by isotope dilution electrospray ionization tandem mass spectrometry. Results: The acylcarnitine profiles of the 3patient groups shared elements with the controls. Considerably higher levels of almost all short-chain acylcarnitines (p <0.05) and lower levels of some long-chain acylcarnitines were detected in T2D and MetS patients. The amounts of C3 and C4 carnitine were higher and most of the medium-chain and long-chain acylcarnitine levels were lower (p <0.05) in T1D and MetS patients than in the controls. In T1D and T2D, the levels of C3 and C4 acylcarnitines were markedly elevated and some long-chain acylcarnitines were lower than the controls (p <0.05). Moreover, significantly lower concentrations of free-and total carnitine were observed in T1D patients (p <0.05). Conclusions: Profound alterations were detected in acylcarnitine profiles in the 3 patient groups. Similarities in the patterns suggest different degrees of involvement of the same metabolic systems in a systems biology approach.",
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AU - Márton, Magdolna

AU - Mohás, M.

AU - Bagosi, Zoltán

AU - Bujtor, Zoltán

AU - Oroszlán, Tamás

AU - Gasztonyi, B.

AU - Wittmann, I.

AU - Melegh, B.

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N2 - Background/Aims: In type 1 diabetes (T1D), type 2 diabetes (T2D) and metabolic syndrome (MetS), the associated complex metabolomic changes in the involvement of carnitine metabolism in total carnitine ester level has already been documented; here we extended the investigations to the individual acylcarnitines. Methods: The fasting serum acylcarnitine concentrations were determined in 49 T1D, 38 T2D and 38 MetS patients and 40 controls by isotope dilution electrospray ionization tandem mass spectrometry. Results: The acylcarnitine profiles of the 3patient groups shared elements with the controls. Considerably higher levels of almost all short-chain acylcarnitines (p <0.05) and lower levels of some long-chain acylcarnitines were detected in T2D and MetS patients. The amounts of C3 and C4 carnitine were higher and most of the medium-chain and long-chain acylcarnitine levels were lower (p <0.05) in T1D and MetS patients than in the controls. In T1D and T2D, the levels of C3 and C4 acylcarnitines were markedly elevated and some long-chain acylcarnitines were lower than the controls (p <0.05). Moreover, significantly lower concentrations of free-and total carnitine were observed in T1D patients (p <0.05). Conclusions: Profound alterations were detected in acylcarnitine profiles in the 3 patient groups. Similarities in the patterns suggest different degrees of involvement of the same metabolic systems in a systems biology approach.

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KW - Carnitine ester profile

KW - Diabetes mellitus

KW - Mass spectrometry

KW - Metabolic syndrome

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