Silica@zirconia@poly(malic acid) nanoparticles: Promising nanocarriers for theranostic applications

L. Naszályi Nagy, A. Polyak, J. Mihály, Szécsényi, I. Cs Szigyártó, Zs Czégény, E. Jakab, P. Németh, B. Magda, P. Szabó, Zs Veres, K. Jemnitz, I. Bertóti, R. P. Jóba, Gy Trencsényi, L. Balogh, A. Bóta

Research output: Article

5 Citations (Scopus)

Abstract

Silicaatzirconiaatpoly(malic acid) nanocarriers of 110 nm mean diameter were designed, synthesized and characterized for the targeted delivery of diagnostic and therapeutic 99mTc to folate-overexpressing tumors. An important achievement was that a multifunctional l-(-)-malic-acid-based copolymer was formed in situ at the surface of the inorganic cores in a single synthetic step incorporating l-(-)-malic acid, β-cyclodextrin rings, folic acid moieties, and polyethylene glycol chains. Morphological and in-depth structural analysis of the particles proved their core@shell structure. Stability experiments in aqueous media evidenced that stable suspensions can be obtained from the lyophilized powder in 10 mM phosphate buffer at pH 7.4. During 14-day degradation experiments, the nanoparticles were found to be slowly dissolving (including inorganic core) in saline and also in total cell medium. An in vitro toxicity assay on hepatocytes showed a concentration-dependent decrease of cell viability down to 63 ± 1% at the highest applied concentration (0.5 mg ml-1). Proof of concept experiments of technetium-99m radiolabelling and in vivo labelling stability are presented.

Original languageEnglish
Pages (from-to)4420-4429
Number of pages10
JournalJournal of Materials Chemistry B
Volume4
Issue number25
DOIs
Publication statusPublished - jan. 1 2016

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ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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