SignaFish: A Zebrafish-specific signaling pathway resource

Kitti Csályi, Dávid Fazekas, Tamás Kadlecsik, Dénes Türei, Leila Gul, Balázs Horváth, Dezso Módos, Amanda Demeter, Nóra Pápai, Katalin Lenti, Péter Csermely, Tibor Vellai, Tamás Korcsmáros, Máté Varga

Research output: Article

1 Citation (Scopus)

Abstract

Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from human or invertebrate model organisms. We previously developed SignaLink, a uniformly curated, multi-layered signaling resource containing information for human and for the model organisms nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster. Until now, the use of the SignaLink database for zebrafish pathway analysis was limited. To overcome this limitation, we created SignaFish (http://signafish.org), a fish-specific signaling resource, built using the concept of SignaLink. SignaFish contains more than 200 curation-based signaling interactions, 132 further interactions listed in other resources, and it also lists potential miRNA-based regulatory connections for seven major signaling pathways. From the SignaFish website, users can reach other web resources, such as ZFIN. SignaFish provides signaling or signaling-related interactions that can be examined for each gene or downloaded for each signaling pathway. We believe that the SignaFish resource will serve as a novel navigating point for experimental design and evaluation for the zebrafish community and for researchers focusing on nonmodel fish species, such as cyclids.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalZebrafish
Volume13
Issue number6
DOIs
Publication statusPublished - jan. 1 2016

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology

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  • Cite this

    Csályi, K., Fazekas, D., Kadlecsik, T., Türei, D., Gul, L., Horváth, B., Módos, D., Demeter, A., Pápai, N., Lenti, K., Csermely, P., Vellai, T., Korcsmáros, T., & Varga, M. (2016). SignaFish: A Zebrafish-specific signaling pathway resource. Zebrafish, 13(6), 541-544. https://doi.org/10.1089/zeb.2016.1277