Siderophore analogues: A new macrocyclic tetraamine tris(hydroxamate) ligand; synthesis and solution chemistry of the iron(III), aluminium(III) and copper(II) complexes

Margarida Gaspar, Raquel Grazina, Andrea Bodor, Etelka Farkas, M. Amélia Santos

Research output: Article

37 Citations (Scopus)

Abstract

A new siderophore analogue TETMAHA (1,4,8,11-tetraazacyclotetradecane-N,N′,N″-tris(N- methylacetohydroxamic acid), a ligand with three hydroxamic acid groups bonded to the macrocycle CYCLAM, has been synthesized and characterized. Its acid-base and chelating properties towards iron(III), aluminium(III) and copper(II) have been studied by potentiometric and spectroscopic techniques. This ligand forms quite stable complexes with those metal ions and the formation constants have been determined. The mechanism of the electron transfer of the iron complexes, thought to be important in the biological activity shown by this ligand, has also been studied by cyclic voltammetry.

Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalJournal of the Chemical Society - Dalton Transactions
Issue number5
DOIs
Publication statusPublished - márc. 7 1999

ASJC Scopus subject areas

  • Chemistry(all)

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