Abstract
Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two genders during ischemia/reperfusion injury. In male and female Wistar rats, renal ischemia was induced followed by a reperfusion period of two, eight, 16, 24, or 48 h. We applied flow cytometry to measure renin content and multiphoton imaging to visualize renin granules and changes of peritubular diameters in vivo during ischemia/reperfusion. Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. In males, the production of renin was more pronounced, and the duration of vasoconstriction was longer with a subsequent phase of vessel hyperdilation compared to females. Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain the different dynamism of renal vessel regulation between the two genders.
| Original language | English |
|---|---|
| Pages (from-to) | 619-626 |
| Number of pages | 8 |
| Journal | Pediatric Transplantation |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - aug. 1 2016 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury. / Csohány, Rózsa; Prókai, Ágnes; Sziksz, Erna; Balicza-Himer, Leonóra; Pap, Domonkos; Kosik, Anna; Sugár, Dániel; Vannay, A.; Kis-Petik, Katalin; Fekete, Andrea; Szabó, Attila J.
In: Pediatric Transplantation, Vol. 20, No. 5, 01.08.2016, p. 619-626.Research output: Article
}
TY - JOUR
T1 - Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury
AU - Csohány, Rózsa
AU - Prókai, Ágnes
AU - Sziksz, Erna
AU - Balicza-Himer, Leonóra
AU - Pap, Domonkos
AU - Kosik, Anna
AU - Sugár, Dániel
AU - Vannay, A.
AU - Kis-Petik, Katalin
AU - Fekete, Andrea
AU - Szabó, Attila J.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two genders during ischemia/reperfusion injury. In male and female Wistar rats, renal ischemia was induced followed by a reperfusion period of two, eight, 16, 24, or 48 h. We applied flow cytometry to measure renin content and multiphoton imaging to visualize renin granules and changes of peritubular diameters in vivo during ischemia/reperfusion. Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. In males, the production of renin was more pronounced, and the duration of vasoconstriction was longer with a subsequent phase of vessel hyperdilation compared to females. Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain the different dynamism of renal vessel regulation between the two genders.
AB - Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two genders during ischemia/reperfusion injury. In male and female Wistar rats, renal ischemia was induced followed by a reperfusion period of two, eight, 16, 24, or 48 h. We applied flow cytometry to measure renin content and multiphoton imaging to visualize renin granules and changes of peritubular diameters in vivo during ischemia/reperfusion. Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. In males, the production of renin was more pronounced, and the duration of vasoconstriction was longer with a subsequent phase of vessel hyperdilation compared to females. Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain the different dynamism of renal vessel regulation between the two genders.
KW - collecting duct
KW - ischemia/reperfusion injury
KW - multi-photon microscopy
KW - renin
UR - http://www.scopus.com/inward/record.url?scp=84978712151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978712151&partnerID=8YFLogxK
U2 - 10.1111/petr.12712
DO - 10.1111/petr.12712
M3 - Article
C2 - 27090360
AN - SCOPUS:84978712151
VL - 20
SP - 619
EP - 626
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 5
ER -