Henoch-Schönlein-purpura súlyos gastrointestinalis és vesemanifesztációi

Gecse Krisztina, Ondrik Zoltán, Kaizer László, Varga Erika, Lonovics János, Czakó László

Research output: Article

Abstract

INTRODUCTION - Henoch-Schönlein purpura is a systemic small vessel vasculitis characterized by vascular and/or mesangial IgA deposits, primarily affecting the vasculature of the skin, joints, kidneys and gastrointestinal tract. Gastro-intestinal findings of various severity occur in 50 to 85% of the cases. We report on a 70-year-old woman who developed ileocaecal invagination and upper gastrointestinal haemorrhage as manifestations of Henoch- Schönlein purpura. CASE REPORT - The patient presented with two days' history of palpable purpuric rash localized on the lower extremities. Based on the result of the skin biopsy, which showed leukocytoclastic vasculitis, IgA and C3 deposits, Henoch-Schö̈nlein purpura was suspected. On the second night after admission colicky abdominal pain, vomiting and diarrhoea developed. Radiological examination showed an ileocaecal invagination and since symptoms deteriorated caecum resection and ileo-ascendestomy was performed. On the third postoperative day the patient became oligo-anuric, which was attributed to her Henoch-Schönlein disease, and systemic steroid pulse therapy was given. One month after the admission the patient experienced haematochezia. Emergency upper endoscopy revealed petechiae, haemorrhagic erosions and mucosal oedema, primarily in the descending part of the duodenum. Since these lesions were also considered as presentations of Henoch-Schönlein disease, another bolus of parenteral steroid was administered. Upper endoscopy repeated 3 days later showed remarkable improvement of the gastric and intestinal lesions. CONCLUSION - Gastrointestinal symptoms are common manifestations of Henoch-Schönlein purpura, thus their recognition, in which endoscopy plays a crucial role, is of major importance. Methylprednisolone pulse therapy is an effective therapeutic option not only in the management of severe renal or joint symptoms, but also in the treatment of gastrointestinal manifestations.

Translated title of the contributionSevere gastrointestinal and renal manifestations of Henoch-Schönlein purpura
Original languageHungarian
Pages (from-to)321-326
Number of pages6
JournalLege Artis Medicinae
Volume17
Issue number4-5
Publication statusPublished - ápr. 1 2007

Keywords

  • Endoscopy
  • Gastrointestinal manifestations
  • Henoch-Schönlein purpura
  • Methylprednisolone pulse therapy

ASJC Scopus subject areas

  • Medicine(all)

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