Serum osteoprotegerin level, carotid-femoral pulse wave velocity and cardiovascular survival in haemodialysis patients

Gábor Speer, Bertalan Cs Fekete, Taha El Hadj Othmane, Tamás Szabó, József Egresits, Erzsébet Fodor, István Kiss, Alexander G. Logan, János Nemcsik, András Szabó, Zsófia K. Németh, Miklós Szathmári, András Tislér

Research output: Article

37 Citations (Scopus)

Abstract

Background. Osteoprotegerin (OPG) is a marker and regulator of arterial calcification, and it is related to cardiovascular survival in haemodialysis patients. The link between OPG and aortic stiffening - a consequence of arterial calcification - has not been previously evaluated in this population, and it is not known whether OPG-related mortality risk is mediated by arterial stiffening. Methods. At baseline, OPG and aortic pulse wave velocity (PWV) were measured in 98 chronic haemodialysis patients who were followed for a median of 24 months. The relationship between OPG and PWV was assessed by multivariate linear regression. The role of PWV in mediating OPG related cardiovascular mortality was evaluated by including both OPG and PWV in the same survival model. Results. At baseline mean (standard deviation) PWV was 11.2 (3.3) m/s and median OPG (interquartile range) was 11.1 (7.5-15.9) pmol/L. There was a strong, positive, linear relationship between PWV and lnOPG (P = 0.009, model R2 = 0.540) independent of covariates. During follow-up 23 patients died of cardiovascular causes. In separate univariate survival models both PWV and lnOPG were related to cardiovascular mortality [hazard ratios 1.31 (1.14-1.50) and 8.96 (3.07-26.16), respectively]. When both PWV and lnOPG were entered into the same model, only lnOPG remained significantly associated with cardiovascular mortality [hazard ratio 1.11 (0.93-1.33) and 7.18 (1.89-27.25), respectively). Conclusion. In haemodialysis patients OPG is strongly related to PWV and OPG related cardiovascular mortality risk is, in part, mediated by increased PWV.

Original languageEnglish
Pages (from-to)3256-3262
Number of pages7
JournalNephrology Dialysis Transplantation
Volume23
Issue number10
DOIs
Publication statusPublished - okt. 1 2008

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    Speer, G., Fekete, B. C., El Hadj Othmane, T., Szabó, T., Egresits, J., Fodor, E., Kiss, I., Logan, A. G., Nemcsik, J., Szabó, A., Németh, Z. K., Szathmári, M., & Tislér, A. (2008). Serum osteoprotegerin level, carotid-femoral pulse wave velocity and cardiovascular survival in haemodialysis patients. Nephrology Dialysis Transplantation, 23(10), 3256-3262. https://doi.org/10.1093/ndt/gfn242