Serum amyloid P component induces neuronal apoptosis and β-amyloid immunoreactivity

Zoltán Urbányi, Lajos László, Thomas B. Tomasi, Erzsébet Tóth, Éva Mekes, Miklós Sass, Tamás Pázmány

Research output: Article

14 Citations (Scopus)

Abstract

Previously we have reported serum amyloid P component (SAP) induced cell death in cerebro-cortical cultures of rat brain. In this paper we studied the types of target cells and the molecular mechanism of SAP-induced cell death. Immuno-electron and light microscopy revealed that SAP penetrates the plasma membrane and translocates selectively into the nuclei of neurons. Neuronal cells with SAP immunoreactivity exhibit the morphological hallmarks of apoptosis in vitro. The apoptotic mechanism of cell death is also supported by the increased Bax/Bcl-2 ratio. In addition to neurotoxic effects, we detected elevated β-amyloid (Aβ) immunoreactivity following SAP treatment. This study supports the thesis that SAP plays an important role in the pathomechanism of neurodegenerative diseases, including Alzheimer's disease by inducing neuronal apoptosis.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalBrain research
Volume988
Issue number1-2
DOIs
Publication statusPublished - okt. 24 2003

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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