Serotonin-CRF interaction in the bed nucleus of the stria terminalis: A light microscopic double-label immunocytochemical analysis

Clyde F. Phelix, Zsolt Liposits, Willis K. Paull

Research output: Article

42 Citations (Scopus)

Abstract

The purpose of the present study was to examine in the bed nucleus of the stria terminalis (BST) of the rat brain the morphological characteristics of interactions between corticotropin-releasing factor (CRF)-producing neuron populations and serotonin (5-HT) axons. A double-label immunocytochemical, light microscopic technique was used to demonstrate axosomatic and axodendritic interactions between 5-HT axons and CRF neurons in the BST. Both the dorsolateral and ventrolateral subpopulations of CRF neurons were targets for the 5-HT afferents. Projections of monoamine neurons to the BST and the CRF neurons that are in the BST are implicated as being major contributors to the neurochemically mediated central regulation of the stress response.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalBrain Research Bulletin
Volume28
Issue number6
DOIs
Publication statusPublished - jún. 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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