Separation of steroidal drugs on porous graphitized carbon column

Research output: Article

15 Citations (Scopus)

Abstract

The retention time of 11 steroidal drugs was determined on a porous graphitized carbon (PGC) column using water-tetrahydrofuran mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor (k') and the tetrahydrofuran concentration in the eluent. To find the molecular parameters significantly influencing the retention the intercept and slope values of the above relationship were correlated with the physicochemical characteristics of steroidal drugs using principal component analysis (PCA). Both the slope and intercept values show high differences proving that steroidal drugs can be successfully separated on a PGC column. Five principal components explained >90% of the total variance. Calculations indicated that both electrostatic interactions and sterical conditions can influence the retention of steroidal drugs on PGC column. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume18
Issue number1-2
DOIs
Publication statusPublished - okt. 1998

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Carbon
Pharmaceutical Preparations
Coulomb interactions
Principal Component Analysis
Static Electricity
Principal component analysis
Water
tetrahydrofuran

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

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title = "Separation of steroidal drugs on porous graphitized carbon column",
abstract = "The retention time of 11 steroidal drugs was determined on a porous graphitized carbon (PGC) column using water-tetrahydrofuran mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor (k') and the tetrahydrofuran concentration in the eluent. To find the molecular parameters significantly influencing the retention the intercept and slope values of the above relationship were correlated with the physicochemical characteristics of steroidal drugs using principal component analysis (PCA). Both the slope and intercept values show high differences proving that steroidal drugs can be successfully separated on a PGC column. Five principal components explained >90{\%} of the total variance. Calculations indicated that both electrostatic interactions and sterical conditions can influence the retention of steroidal drugs on PGC column. Copyright (C) 1998 Elsevier Science B.V.",
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T1 - Separation of steroidal drugs on porous graphitized carbon column

AU - Forgács, E.

AU - Cserháti, T.

PY - 1998/10

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N2 - The retention time of 11 steroidal drugs was determined on a porous graphitized carbon (PGC) column using water-tetrahydrofuran mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor (k') and the tetrahydrofuran concentration in the eluent. To find the molecular parameters significantly influencing the retention the intercept and slope values of the above relationship were correlated with the physicochemical characteristics of steroidal drugs using principal component analysis (PCA). Both the slope and intercept values show high differences proving that steroidal drugs can be successfully separated on a PGC column. Five principal components explained >90% of the total variance. Calculations indicated that both electrostatic interactions and sterical conditions can influence the retention of steroidal drugs on PGC column. Copyright (C) 1998 Elsevier Science B.V.

AB - The retention time of 11 steroidal drugs was determined on a porous graphitized carbon (PGC) column using water-tetrahydrofuran mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor (k') and the tetrahydrofuran concentration in the eluent. To find the molecular parameters significantly influencing the retention the intercept and slope values of the above relationship were correlated with the physicochemical characteristics of steroidal drugs using principal component analysis (PCA). Both the slope and intercept values show high differences proving that steroidal drugs can be successfully separated on a PGC column. Five principal components explained >90% of the total variance. Calculations indicated that both electrostatic interactions and sterical conditions can influence the retention of steroidal drugs on PGC column. Copyright (C) 1998 Elsevier Science B.V.

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