Separation of enantiomers by supercritical fluid extraction

Research output: Article

27 Citations (Scopus)

Abstract

The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalJournal of Supercritical Fluids
Volume13
Issue number1-3
DOIs
Publication statusPublished - jún. 15 1998

Fingerprint

Supercritical fluids
Enantiomers
supercritical fluids
enantiomers
acids
Acids
Phenethylamines
products
Experiments
Temperature
temperature

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Chemical Engineering(all)
  • Condensed Matter Physics

Cite this

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title = "Separation of enantiomers by supercritical fluid extraction",
abstract = "The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.",
keywords = "Enantiomer, Experimental design, Racemate, Resolution, Supercritical extraction",
author = "B. Sim{\'a}ndi and S. Keszei and E. Fogassy and S. Kem{\'e}ny and J. Sawinsky",
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T1 - Separation of enantiomers by supercritical fluid extraction

AU - Simándi, B.

AU - Keszei, S.

AU - Fogassy, E.

AU - Kemény, S.

AU - Sawinsky, J.

PY - 1998/6/15

Y1 - 1998/6/15

N2 - The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.

AB - The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.

KW - Enantiomer

KW - Experimental design

KW - Racemate

KW - Resolution

KW - Supercritical extraction

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EP - 336

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

SN - 0896-8446

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