Separation of enantiomers and control of elution order of β-lactams by GC using cyclodextrin-based Chiral stationary phases

Ke Huang, Daniel W. Armstrong, Eniko Forro, Ferenc Fulop, Antal Peter

Research output: Article

5 Citations (Scopus)


Enantiomers of 19 racemic β-lactams, with 3 and 4-position substitutions, were separated using gas chromatography. Excellent results were achieved on derivatized cyclodextrin-based GC chiral stationary phases (CSPs). All 19 compounds were baseline separated, most with high resolution factors. The Chiraldex G-TA was found to be the most powerful CSP with the broadest enantioselectivity, while Chiraldex B-DM produced the fastest separations for most of the compounds assayed. Results obtained in this work suggest that GC can serve as a potential method for the enantiomeric separation of sufficiently volatile solid β-lactams.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
Issue number3-4
Publication statusPublished - febr. 1 2009


ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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