Self-rated health status in spinocerebellar ataxia - Results from a European multicenter study

Tanja Schmitz-Hübsch, Mathieu Coudert, Paola Giunti, Christoph Globas, L. Balikó, Roberto Fancellu, Caterina Mariotti, Alessandro Filla, Maryla Rakowicz, Perrine Charles, Pascale Ribai, Sandra Szymanski, Jon Infante, Bart P C Van De Warrenburg, Alexandra Dürr, Dagmar Timmann, Sylvia Boesch, Rafal Rola, Chantal Depondt, Ludger SchölsElszbieta Zdzienicka, Jun Suk Kang, Susanne Ratzka, Berry Kremer, Jörg B. Schulz, Thomas Klopstock, B. Melegh, Sophie Tezenas Du Montcel, Thomas Klockgether

Research output: Article

37 Citations (Scopus)

Abstract

Patient-based measures of subjective health status are increasingly used as outcome measures in interventional trials. We aimed to determine the variability and predictors of subjective health ratings in a possible target group for future interventions: the spinocerebellar ataxias (SCAs). A consecutive sample of 526 patients with otherwise unexplained progressive ataxia and genetic diagnoses of SCA1 (117), SCA2 (163), SCA3 (139), and SCA6 (107) were enrolled at 18 European referral centers. Subjective health status was assessed with a generic measure of health related quality of life, the EQ-5D (Euroqol) questionnaire. In addition, we performed a neurological examination and a screening questionnaire for affective disorders (patient health questionnaire). Patient-reported health status was compromised in patients of all genotypes (EQ-5D visual analogue scale (EQVAS) mean 61.45 ± 20.8). Specifically, problems were reported in the dimensions of mobility (86.9% of patients), usual activities (68%), pain/discomfort (49.4%), depression/ anxiety (46.4%), and self care (38.2%). Multivariate analysis revealed three independent predictors of subjective health status: ataxia severity, extent of noncerebellar involvement, and the presence of depressive syndrome. This model explained 30.5% of EQ-VAS variance in the whole sample and might be extrapolated to other SCA genotypes.

Original languageEnglish
Pages (from-to)587-595
Number of pages9
JournalMovement Disorders
Volume25
Issue number5
DOIs
Publication statusPublished - ápr. 15 2010

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Spinocerebellar Ataxias
Health Status
Multicenter Studies
Diagnostic Self Evaluation
Ataxia
Genotype
Neurologic Examination
Depressive Disorder
Self Care
Mood Disorders
Visual Analog Scale
Referral and Consultation
Multivariate Analysis
Anxiety
Quality of Life
Outcome Assessment (Health Care)
Depression
Pain
Health
Surveys and Questionnaires

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Schmitz-Hübsch, T., Coudert, M., Giunti, P., Globas, C., Balikó, L., Fancellu, R., ... Klockgether, T. (2010). Self-rated health status in spinocerebellar ataxia - Results from a European multicenter study. Movement Disorders, 25(5), 587-595. https://doi.org/10.1002/mds.22740

Self-rated health status in spinocerebellar ataxia - Results from a European multicenter study. / Schmitz-Hübsch, Tanja; Coudert, Mathieu; Giunti, Paola; Globas, Christoph; Balikó, L.; Fancellu, Roberto; Mariotti, Caterina; Filla, Alessandro; Rakowicz, Maryla; Charles, Perrine; Ribai, Pascale; Szymanski, Sandra; Infante, Jon; Van De Warrenburg, Bart P C; Dürr, Alexandra; Timmann, Dagmar; Boesch, Sylvia; Rola, Rafal; Depondt, Chantal; Schöls, Ludger; Zdzienicka, Elszbieta; Kang, Jun Suk; Ratzka, Susanne; Kremer, Berry; Schulz, Jörg B.; Klopstock, Thomas; Melegh, B.; Du Montcel, Sophie Tezenas; Klockgether, Thomas.

In: Movement Disorders, Vol. 25, No. 5, 15.04.2010, p. 587-595.

Research output: Article

Schmitz-Hübsch, T, Coudert, M, Giunti, P, Globas, C, Balikó, L, Fancellu, R, Mariotti, C, Filla, A, Rakowicz, M, Charles, P, Ribai, P, Szymanski, S, Infante, J, Van De Warrenburg, BPC, Dürr, A, Timmann, D, Boesch, S, Rola, R, Depondt, C, Schöls, L, Zdzienicka, E, Kang, JS, Ratzka, S, Kremer, B, Schulz, JB, Klopstock, T, Melegh, B, Du Montcel, ST & Klockgether, T 2010, 'Self-rated health status in spinocerebellar ataxia - Results from a European multicenter study', Movement Disorders, vol. 25, no. 5, pp. 587-595. https://doi.org/10.1002/mds.22740
Schmitz-Hübsch, Tanja ; Coudert, Mathieu ; Giunti, Paola ; Globas, Christoph ; Balikó, L. ; Fancellu, Roberto ; Mariotti, Caterina ; Filla, Alessandro ; Rakowicz, Maryla ; Charles, Perrine ; Ribai, Pascale ; Szymanski, Sandra ; Infante, Jon ; Van De Warrenburg, Bart P C ; Dürr, Alexandra ; Timmann, Dagmar ; Boesch, Sylvia ; Rola, Rafal ; Depondt, Chantal ; Schöls, Ludger ; Zdzienicka, Elszbieta ; Kang, Jun Suk ; Ratzka, Susanne ; Kremer, Berry ; Schulz, Jörg B. ; Klopstock, Thomas ; Melegh, B. ; Du Montcel, Sophie Tezenas ; Klockgether, Thomas. / Self-rated health status in spinocerebellar ataxia - Results from a European multicenter study. In: Movement Disorders. 2010 ; Vol. 25, No. 5. pp. 587-595.
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