Selective up-regulation of neuropeptide synthesis by blocking the neuronal activity: Galanin expression in septohippocampal neurons

Denes V. Agoston, Samuel Komoly, Miklos Palkovits

Research output: Article

36 Citations (Scopus)

Abstract

Neuronal activity regulates expression of phenotype-specific genes, including galanin, which coexists with choline acetyltransferase in septal and basal forebrain neurons. Transections of the fornix and the diagonal band alter galanin expression in septohippocampal neurons attributed to a deficit in target-derived trophic factors. The present study demonstrates that tetrodotoxin-induced blockade of neuronal activity fully mimicked the effect of axotomy (transection of the septohippocampal fibers) in the neurons of the nucleus of the diagonal band, and caused a dramatic, although temporary, up-regulation of galanin immunoreactivity and galanin mRNA without significant alteration in choline acetyltransferase expression. This finding suggests that in the septohippocampal cholinergic system perturbance of electrical activity alone can lead to temporary up-regulation of galanin expression, previously attributed exclusively to a “lesion effect”.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalExperimental Neurology
Volume126
Issue number2
DOIs
Publication statusPublished - ápr. 1994

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Fingerprint Dive into the research topics of 'Selective up-regulation of neuropeptide synthesis by blocking the neuronal activity: Galanin expression in septohippocampal neurons'. Together they form a unique fingerprint.

  • Cite this