Deprenyl (phenyl-isopropyl-methyl-propinylamine) is a potent inhibitor of monoamine oxidase (MAO) and like the acetylenic type of inhibitors it induces irreversible inhibition of the enzyme. Its levorotatory isomer is a more potent inhibitor than the dextrorotatory one. Deprenyl elevates the concentration of 3H-noradrenaline (3H-NA) in the synaptosomal fraction of rat heart homogenate while pargyline, probably due to its releasing effect, decreases 3H-NA content in the same fraction. Deprenyl is a selective inhibitor of the 'B form' of MAO, which preferentially oxidizes β-phenylethylamine as substrate.
|Number of pages||14|
|Journal||Polish journal of pharmacology and pharmacy|
|Publication status||Published - dec. 1 1977|
ASJC Scopus subject areas
- Pharmaceutical Science