Selective inhibition of the 'B form' of monoamine oxidase

Research output: Article

17 Citations (Scopus)


Deprenyl (phenyl-isopropyl-methyl-propinylamine) is a potent inhibitor of monoamine oxidase (MAO) and like the acetylenic type of inhibitors it induces irreversible inhibition of the enzyme. Its levorotatory isomer is a more potent inhibitor than the dextrorotatory one. Deprenyl elevates the concentration of 3H-noradrenaline (3H-NA) in the synaptosomal fraction of rat heart homogenate while pargyline, probably due to its releasing effect, decreases 3H-NA content in the same fraction. Deprenyl is a selective inhibitor of the 'B form' of MAO, which preferentially oxidizes β-phenylethylamine as substrate.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalPolish journal of pharmacology and pharmacy
Issue number3
Publication statusPublished - dec. 1 1977


ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this