Selective inhibition of the 'B form' of monoamine oxidase

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Abstract

Deprenyl (phenyl-isopropyl-methyl-propinylamine) is a potent inhibitor of monoamine oxidase (MAO) and like the acetylenic type of inhibitors it induces irreversible inhibition of the enzyme. Its levorotatory isomer is a more potent inhibitor than the dextrorotatory one. Deprenyl elevates the concentration of 3H-noradrenaline (3H-NA) in the synaptosomal fraction of rat heart homogenate while pargyline, probably due to its releasing effect, decreases 3H-NA content in the same fraction. Deprenyl is a selective inhibitor of the 'B form' of MAO, which preferentially oxidizes β-phenylethylamine as substrate.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalPolish journal of pharmacology and pharmacy
Volume29
Issue number3
Publication statusPublished - dec. 1 1977

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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