Benzyloxymethyl (BOM) and benzyl (Bz) groups were employed for protection of the amide- and amino-nitrogens in the title compounds. The BOM protective group could be removed selectively or simultaneously with the Bz group depending on the reaction conditions. By catalytic hydrogenation of the fully protected pyridazinooxazinone (1b), unexpectedly the 4-methyl derivative (1e) could also be prepared. The mechanism for the formation of 1e is also discussed.
|Number of pages||10|
|Publication status||Published - márc. 1 1993|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry