Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy

Marton Graf, R. Jakus, Sandor Kantor, Gyorgy Levay, G. Bagdy

Research output: Article

61 Citations (Scopus)

Abstract

Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNeuroscience Letters
Volume359
Issue number1-2
DOIs
Publication statusPublished - ápr. 8 2004

Fingerprint

Serotonin 5-HT1 Receptor Antagonists
Absence Epilepsy
Receptor, Serotonin, 5-HT1A
Serotonin Receptors
Animal Models
serotonin 7 receptor
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy. / Graf, Marton; Jakus, R.; Kantor, Sandor; Levay, Gyorgy; Bagdy, G.

In: Neuroscience Letters, Vol. 359, No. 1-2, 08.04.2004, p. 45-48.

Research output: Article

@article{e3131d5dbd0f4bcd86e14289f2e1d5c8,
title = "Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy",
abstract = "Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.",
keywords = "5-HT receptor, 5-HT receptor, Absence epilepsy, Animal model, Spike-wave discharges, WAG/Rij rat",
author = "Marton Graf and R. Jakus and Sandor Kantor and Gyorgy Levay and G. Bagdy",
year = "2004",
month = "4",
day = "8",
doi = "10.1016/j.neulet.2004.01.072",
language = "English",
volume = "359",
pages = "45--48",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy

AU - Graf, Marton

AU - Jakus, R.

AU - Kantor, Sandor

AU - Levay, Gyorgy

AU - Bagdy, G.

PY - 2004/4/8

Y1 - 2004/4/8

N2 - Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.

AB - Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT1A receptor antagonist WAY-100635 and the selective 5-HT7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike-wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT1A and 5-HT7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.

KW - 5-HT receptor

KW - 5-HT receptor

KW - Absence epilepsy

KW - Animal model

KW - Spike-wave discharges

KW - WAG/Rij rat

UR - http://www.scopus.com/inward/record.url?scp=1842608901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842608901&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.01.072

DO - 10.1016/j.neulet.2004.01.072

M3 - Article

C2 - 15050708

AN - SCOPUS:1842608901

VL - 359

SP - 45

EP - 48

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -