Salo et al. show that seipin determines where a lipid droplet (LD) forms and establishes a neck between ER and LD. LDs continuously exchange lipids via ER, and biophysically, larger LDs acquire lipids more readily than smaller ones. Seipin facilitates lipid transfer to droplets, helping small LDs to grow.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology