Through the reactions of 2-carboxybenzaldehyde (1) with cis- or trans-2-amino-1-cyclohexylmethylamine (2a,b) or cis- or trans-2-amino-4-cyclohexenyl-1-methylamine (2c,d), the partially saturated isomeric isoindolo[ 1,2-6]- (3, 4, 6-8) and -[2,1-a]quinazolinones (5) were obtained. After separation, the structures of products (3-8) were established by NMR methods, including 2D-HSC DNOE and DEPT measurements. From the cis 2a, two linearly C/D cis-fused and one angularly C/D trans-fused tetracycles were formed.
|Number of pages||6|
|Publication status||Published - dec. 1 1998|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry