Satietin and satietin-D, two closely related 50,000 dalton anorectic glycoproteins were isolated from human serum. The isoelectric point of satietin is 7.0, it contains 14-15% amino acids and 70-75% carbohydrates. Satietin-D has an isoelectric point of 3.0, a protein content of 20-22% and a carbohydrate content of 55-60%. Both satietin and satietin-D are potent, long-acting and highly selective suppressants of food intake in the rat. The hypothesis was forwarded that satietin and satietin-D may belong to a system which brings into being the rate-limiting blood-borne satiety signalization in the negative feedback of food intake.
|Number of pages||8|
|Journal||Progress in clinical and biological research|
|Publication status||Published - dec. 1 1985|
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