Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma

G. Cserni, Rita Beáta Kovács, Miklós Tarján, Z. Sápi, Zsolt Domján, Zoltán Szabó

Research output: Article

10 Citations (Scopus)

Abstract

Both chromophobe carcinoma and sarcomatoid carcinoma of the kidney are rare. The former is characterized by a relatively good prognosis, while the latter is a highly aggressive tumor. Coexistence of the two components in one renal tumor, which has been reported only rarely, is therefore paradoxical. Both sarcomatoid and chromophobe renal carcinoma were diagnosed in a 52-year-old woman following nephrectomy and resection of metastases in the right lobe of the liver. She died of the disease two months after the first operation; only the sarcomatoid component of her tumor was seen in the liver metastasis and the recurrent carcinoma. Differences in phenotype, immunophenotype and DNA-ploidy patterns of the two components are reported. The intensive p53 staining observed only in the sarcomatoid area supports the role of the TP53 gene in the transformation of chromophobe renal carcinoma to sarcomatoid carcinoma.

Original languageEnglish
Pages (from-to)142-144
Number of pages3
JournalPathology and Oncology Research
Volume8
Issue number2
Publication statusPublished - 2002

Fingerprint

Renal Cell Carcinoma
Carcinoma
Kidney
Neoplasm Metastasis
Neoplasms
Ploidies
Liver
p53 Genes
Nephrectomy
Staining and Labeling
Phenotype
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Cserni, G., Kovács, R. B., Tarján, M., Sápi, Z., Domján, Z., & Szabó, Z. (2002). Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. Pathology and Oncology Research, 8(2), 142-144.

Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. / Cserni, G.; Kovács, Rita Beáta; Tarján, Miklós; Sápi, Z.; Domján, Zsolt; Szabó, Zoltán.

In: Pathology and Oncology Research, Vol. 8, No. 2, 2002, p. 142-144.

Research output: Article

Cserni, G, Kovács, RB, Tarján, M, Sápi, Z, Domján, Z & Szabó, Z 2002, 'Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma', Pathology and Oncology Research, vol. 8, no. 2, pp. 142-144.
Cserni, G. ; Kovács, Rita Beáta ; Tarján, Miklós ; Sápi, Z. ; Domján, Zsolt ; Szabó, Zoltán. / Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. In: Pathology and Oncology Research. 2002 ; Vol. 8, No. 2. pp. 142-144.
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