Role of parathymic lymph nodes in metastatic tumor development.

Research output: Review article

9 Citations (Scopus)

Abstract

Parathymic lymph nodes as potential sites of tumor progression have been neglected in humans. We have established a rat renal capsule-parathymic lymph node model to study in vivo metastasis. Epithelial liver carcinoma (HeDe) and mesenchymal mesoblastic nephroma (NeDe) cell lines have been established after inducing chemical carcinogenesis in newborn Fisher 344 inbred rats by N-nitrosodimethylamine. Implanting the exact number of tumor cells (HeDe, NeDe) under the renal capsule allowed the standardization and timing of metastatic development. Tumor cells released from the primary tumor in the peritoneal cavity were drained to the parathymic lymph nodes (PTNs) as sentinel lymph nodes. Similarly, tumor cells injected i.p. were engulfed by macrophages, drained through the transdiaphragmatic channels, and transported to the thoracal lymphatics, primarily to PTNs. Tumor cells after transdiaphragmic drainage can enter both anterior mammary and parathymic sentinel lymph nodes. The potential common origin can shed new light on the metastatic cell progression of PTNs and mammary tumors.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalCancer metastasis reviews
Volume31
Issue number1-2
Publication statusPublished - jan. 1 2012

Fingerprint

Lymph Nodes
Neoplasms
Capsules
Mesoblastic Nephroma
Kidney
Dimethylnitrosamine
Peritoneal Cavity
Inbred F344 Rats
Drainage
Carcinogenesis
Breast
Cell Count
Macrophages
Breast Neoplasms
Neoplasm Metastasis
Carcinoma
Cell Line
Liver
Sentinel Lymph Node

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Role of parathymic lymph nodes in metastatic tumor development. / Bánfalvi, G.

In: Cancer metastasis reviews, Vol. 31, No. 1-2, 01.01.2012, p. 89-97.

Research output: Review article

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